Rx (Ÿ) |
Risk Intervention |
Recommendations |
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Smoking: Goal-Complete
cessation |
Strongly encourage patient
and family to stop smoking. Provide counselling,
nicotine replacement, and formal cessation programs as appropriate. |
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Lipid Management: Primary
goal *
LDL < 2.5 mmol/L
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Start hypolipidemic diet in all patients: £30%
fat,<7%saturated fat,< 200mg/day cholesterol. 10 % LDL ø
achievable with diet. Assess fasting lipid profile. Baseline lipid profile
< 24 after acute event. In post -MI patients, lipid profile may take 4 to
6 weeks to stabilize. Add drug therapy according to the following guide: |
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Secondary goal *TC/HDL < 4 Tertiary goal * Metabolic Syndrome TG < 1.7 mmol/L HDL Ò 1.0mmol/L(men)/ Ò
1.3mmol/L (women) |
LIPID Profile |
1st Line Therapy |
2nd Line Therapy |
LDL
Ð
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Statin |
Resin |
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LDL ÐÐ & TG Ð |
Statin |
Niacin or Fibrate |
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LDL Ð & TG Ð & HDL ø |
Fibrate or Niacin |
Combination Therapy |
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* Primary goal: For patients CHD Risk equivalent: any of CAD, TIA, CVA, AAA, PVD/bruits, DM with one additional categorical risk factor or for patients with very high 10-year risk for hard CV events (Ò 20%). á Target initial therapy with the medication dose required to achieve target LDL < 2.5 mmol/L. á
For 10 yr CV risk for hard
endpoints 10-20%, LDL target is 3.5 mmol/L. á
For 10 yr CV risk for hard
endpoints < 10%, LDL target
is 4.5 mmol/L. á
Initiate lipid lowering early in high-risk patients (in
conjunction with dietary modification). For
specific medications and dosing strategy see Lipid
Optimization Tool
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Blood
pressure control: Goal £135/85
mm Hg 2002 CHS Guidelines released
May 2003 |
á
Initiate lifestyle
modification in all patients with blood pressure >
140 systolic or > 90 diastolic
over 3 visits with target organ damage (TOD) or 5 visits with no TOD.
Initiate Rx immediately if BP > 180/105. á
Initial Rx for
systolic/diastolic HTN in absence of compelling indication: Low dose
thiazide; ACE-I /ARB; long-acting DHP-CCB; b-blocker.
No age distinction in initial therapy. á
Use Rx individualized to
patient requirements if associated risk factors, target organ damage or
concomitant disease/condition á
Isolated systolic HTN:
LDD/long-acting DHP-CCB/ARB á
Avoid b-blocker
or a-blocker as initial Rx HTN Ò
60yr. á
ACE-I not recommended for
blacks without another compelling indication. á
Type 2 diabetes with
micro-albuminuria, proteinuria or nephropathy ACE-I/ARBs are 1st
line Rx |
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Diabetes 2003 CDA Guidelines released Dec
2003 |
á
Dx DM: FBG Ò 7.0 mmol/L or
2 hr PCGÒ11.1
mmol/L.(Normal: A1C ≤ 6; FG 4-6
mmol/L; 2 hr PCG 5-8 mmol/L. IFG 6.1-6.9 mmol/L. IGT 2 hr PCG 7.8-11 mmol/L).
á
Target euglycemia ASAP. Initiate diet¨weight loss
(5-10%), diabetes education & exercise program. Target A1C ≤ 7; FG 4-7
mmol/L; 2 hr PCG 5-10 mmol/L. Rx oral hypoglycemic for FBG Ò 7.0 mmol/L
& A1C 7-9.Consider initial combination Rx for A1C ≥9 mmol/L.
á
Aggressive BP control. Target <130/80 Rx ACE-i ,
ARB, cardio-selective b-blocker, thiazide diuretic, long acting CCB. BP
target 125/75 for diabetic nephropathy eliminated. (differs from CHS)
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Physical
activity: Minimum goal
30 minutes 3 to 5
times/week
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á
Assess risk, preferably with exercise test, to guide
prescription. á
Encourage minimum of 30-40 minutes of moderate
intensity activity 3 to 5 times weekly
(walking, jogging, cycling or other aerobic activity) supplemented by
an increase in daily lifestyle activities (e.g., walking breaks at work,
using stairs, gardening, household work) á
Max benefits 5 to 6 hours per week. Medically
supervised programs for moderate to high-risk patients. |
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Obesity/weight management: |
Start intensive diet and
appropriate physical activity intervention, as outlined above, in patients >120%
of ideal weight for height. Particularly emphasise need for weight loss in
patients with hypertension, elevated triglycerides or elevated glucose
levels. Ideal body weight BMI < 25. |
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Antiplatelet
agents/ anticoagulants: |
Start aspirin 80-325 mg per day if not contraindicated. Consider clopidogrel 75mg OD post MI, post CABG, CVA, PVD in ASA intolerant or allergic patients (CAPRIE Trial). Consider clopidogrel 75mg OD + ASA for ACS: unstable angina/non-ST elevation MI (CURE Trial: duration of therapy 9-12 months) Consider warfarin for post
MI patients not able to take aspirin (maintain INR 2-3). |
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ACE
inhibitors Post-MI/LV
Dysfunction: |
Start early post-MI in
stable high risk patients (anterior MI, previous MI, Killip class II (S3
gallop, rales, radiographic CHF). Continue indefinitely for all with LV
dysfunction (EF<40%) or symptoms
of CHF. Use as needed to manage HPT
or symptoms in all other patients. |
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ACE
inhibitors Vascular
disease/Diabetes |
Rx ACE inhibitors in all patients >55 yrs with evidence of vascular disease or DM and
one other risk factor: HOPE
Trial-Ramipril 2.5¨10 mg OD or all CAD patients >18 yrs EUROPA
Trial-Perindopril 4¨8 mg OD |
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Beta-blockers: Post-MI |
Start acutely or within a
few days of event in all post-MI patients (unless contra-indication).
Continue indefinitely if residual ischemia, heart failure,LV dysfunction or
severe co-morbidity. Continue
indefinitely in low risk
patients (IIa). Rx as needed to manage angina, arrhythmia or HPT. |
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Beta-blockers: CHF |
Rx Beta-blocker to ACE-inhibitor/diuretic/+/- digoxin
in stable Class II-IV CHF/LVEF £ 40% Bisoprolol
1.25 ¨ 10 mg OD, carvedilol 3.125 mg
BID ¨ 25 mg BID (50 mg BID if
weight > 85 kg) or metoprolol 12.5 mg ¨
75-100 mg BID |
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Homocyst(e)ine Target £ 10 mmol/L |
Check in patients with
premature CAD/CVD/PVD; family history premature atherosclerosis or manifest
atherosclerosis & no identifiable risk factors. Folic acid 2.5 mg, B6 25
mg, B12 250 mcg. |
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Estrogens: |
HRT not recommended for 10
prevention. Use established
preventative strategies. Consider HRT or SERMS for non-cardiac indications.
Individualize recommendations consistent with other health risks (VTE,
endometrial or breast CA). HRT
not indicated in 20 prevention.
D/C HRT in ACS, MI, PTCA,CABG,CHF,Sx. |
Rx (Ÿ) |
Risk Intervention |
Date Ÿ Achieved |
Date Ÿ Achieved |
Date Ÿ Achieved |
Date Ÿ Achieved |
Date Ÿ Achieved |
Date Ÿ Achieved |
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Ideal body weight:
BMI < 25 __________ Target ____________ |
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Girth: Targets F< 90 cm M< 100 cm |
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Physical activity: Minimum
goal
30 minutes 3 to 5 times/week (total/wk) |
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Smoking Goal: Complete cessation |
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Lipid Management: |
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Primary goal:
LDL < 2.5 mmol/L |
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Secondary goal_
TC/HDL< 4 |
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Metabolic Syndrome HDL Ò 1.0 mmol/L M HDL Ò 1.3 mmol/L F |
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TG < 1.7 mmol/L |
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Blood pressure: Target £135/85 mm Hg on home BP/ABP |
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Diabetes: Targets
FBS 4-7 mmol/L 2hr PCG 5-10 mmol/L A1C £ 7% |
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MAU: Targets Spot urine < 20 mg/L ACR < 2.0 Men ACR < 2.8 Women |
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Antiplatelet agents: |
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Anticoagulants: Target INR ______ |
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ACE inhibitors: Post-MI |
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ACE inhibitors: Vascular disease |
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Beta-blockers: Post-MI |
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Beta-blockers/CHF: |
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Homocyst(e)ine
£
10 mmol/L
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LP(a) < 30
mg/dL
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hs-CRP< 3.0
mg/L
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HRT: On/off |
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