Lozol (indapamide)
Novo Nordisk
About Lozol

High blood pressure increases the workload of the heart and arteries. If this condition persists, damage to the blood vessels that supply the brain, heart or kidneys may occur. This may result in stroke, heart failure, heart attack or kidney failure. By reducing high blood pressure, the risk of developing these conditions decreases.

Lozol belongs to a class of medications known as diuretics (commonly called water pills). This medication is primarily used in the treatment of hypertension (high blood pressure). It is also used to treat edema (fluid retention) caused by congestive heart failure. Lozol works by increasing the amount of salts (sodium and potassium) that are filtered out of the blood and into the urine by the kidneys. Water is also removed from the body along with these salts and, as a result, urine output is increased. The use of indapamide was approved by the FDA in 1983.

Dosage and Forms

Lozol is available as tablets for oral administration containing 1.25mg or 2.5mg of indapamide.

When used as treatment for hypertension:
  • The adult starting dose of indapamide is generally 1.25mg once daily, taken orally (usually in the morning).
  • If an adequate clinical response is not observed after four weeks, the dose should be increased to 2.5mg once daily.
  • The dose may be increased further to a maximum dose of 5mg once daily if satisfactory results have not been achieved, however, the addition of another antihypertensive agent should be considered.
When used as treatment for fluid retention associated with congestive heart failure:
  • The adult starting dose is usually 2.5mg once daily, taken in the morning.
  • The dose may be increased to a maximum of 5mg daily if a satisfactory response is not observed after one week.

Before Using Lozol

  • Before taking Lozol, talk to your doctor about any prescription and non-prescription medications you are taking.
  • Talk to your doctor about any medical conditions you have, especially: kidney disease, an inability to urinate, low blood potassium levels, gout, liver disease, lupus, or an allergy to any of the ingredients in Lozol.
  • Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Warnings & Precautions

  • In some cases, indapamide has been found to cause low blood potassium levels (hypokalemia). To help prevent this, your doctor may recommend that you eat or drink foods high in potassium or take potassium supplements.
  • Indapamide reduces the body’s ability to remove lithium. A build up of lithium in your blood can lead to lithium toxicity. If you are taking lithium along with indapamide, lithium levels in your body should be monitored closely.

Side Effects

Minor side effects that may be experienced by some people while taking indapamide include:
  • Dizziness
  • Headache
  • Mild skin rash
The following is a list of more serious side effects that may be experienced by some people while taking indapamide. Talk to your doctor right away if you feel any of the following symptoms:
  • Dry mouth, thirst, nausea, vomiting
  • Feeling weak, drowsy, restless, or light-headed
  • Fast or uneven heartbeat
  • Muscle pain or weakness

Active ingredient: Indapamide

Inactive ingredients: microcrystalline cellulose, coloring agent, corn starch, pregelatinized starch, hypromellose, lactose, magnesium stearate, polyethylene glycol, talc