About Apidra (insulin glulisine)
Apidra (insulin glulisine) is a human insulin analogue that is produced by recombinant DNA technology. It is used in the treatment of type 1 and type 2 diabetes mellitus to control blood sugar levels. Insulin glulisine is chemically identical to regular human insulin other than a slight change in the amino acid sequence. This structural change results in a more rapid onset of action and shorter duration of action than regular insulin.

Apidra is taken as a mealtime insulin. It can be taken within 15 minutes before and up to 20 minutes after starting a meal. Apidra starts to work within 15 minutes after injection, peaks in about one hour, and continues working for 2-4 hours. Therefore, Apidra is able to control the rise in blood glucose levels that occurs about 30 minutes after consuming a meal.

Apidra is used in regimens that include a longer-lasting insulin analogue to maintain glucose levels. It can be used with oral anti-diabetic agents as well.

Dosage forms:

Apidra 100units/mL is available as:
  • 10mL vials
  • 3mL cartridge system
  • 3mL SoloSTAR prefilled disposable pen
Apidra may be used in an insulin pump.

Before Taking Apidra
  • Talk to your doctor about all medications you are currently taking, including prescription and non-prescription medications, vitamins and herbal supplements
  • Talk to your doctor about any medical conditions that you have or have previously had
  • Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding
Side Effects

The most common side effect of insulin, including Apidra, is low blood sugar (hypoglycemia), which may be serious.

Other possible side effects may include:
  • low blood potassium (hypokalemia)
  • injection site reactions
  • allergic reactions
Talk to your doctor if you experience any side effects while taking Apidra.


Active ingredient: insulin glulisine
Inactive ingredients: m-cresol, polysorbate 20, sodium chloride, trometamol, water, sodium hydroxide and hydrochloric acid