Amaryl (glimepiride)
About Amaryl

Amaryl belongs to a class of oral anti-hyperglycemic medications known as sulphonylureas. Amaryl controls blood sugar levels in patients with type 2 diabetes by stimulating the release of insulin from the pancreas. Amaryl may be used alone or in combination with metformin or insulin when adequate blood glucose levels are not achieved with lifestyle management alone.

Dosage and Forms

Amaryl is formulated into tablets for oral administration containing 1mg, 2mg, and 4mg of glimepiride.

Starting Dose: The usual starting dose of Amaryl is 1mg once daily, administered with breakfast.

Maintenance Dose: The usual maintenance dose of Amaryl is 1 to 4mg once daily. After reaching a dose of 2 mg daily, dosage increases should be made in increments of no more than 1 mg at 1-2 week intervals based on the patient's blood glucose response. Long-term efficacy should be monitored by measurement of HbA1C levels.

Maximum Dose: The maximum dose of Amaryl is 8mg once daily.

When Amaryl should not be used

Amaryl should not be used in patients:
  • Who have type 1 diabetes
  • Who are allergic to sulphonylureas, sulfonamides or any of the ingredients in Amaryl
  • Who have diabetic ketoacidosis
  • Who are pregnant or breastfeeding
Side Effects

As with any medication, certain side effects may be experienced while taking Amaryl. The most common of these include:
  • Dizziness
  • Weakness
  • Headache
  • Nausea
  • Hypoglycemia (low blood sugar)